Organic Acid Test (OAT) – FMD

FM Diagnostics - A NABL Approved Lab

Organic Acid Test (OAT)


Test Parameters:

Organic acids are chemical compounds excreted in the urine of mammals that are products of metabolism. Metabolism is the sum of chemical reactions in living beings by which the body builds new molecules and breaks down molecules to eliminate waste products and produce energy.

Reporting Time: 2-4 weeks
Organic Acid Test
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Product Description

The Organic Acids Test uses an easy-to-collect, first morning void specimen to evaluate organic acids in urine. Test results highlight areas of dysfunction that can be impacted by epigenetic, nutritional, environmental, lifestyle, and other key factors.Dysfunctional metabolic pathways can negatively impact mood, energy production, and overall health while also providing insight into nutrient insufficiency, diet composition, toxic exposures, and microbial metabolism.

The personalized information generated in the Organic Acids Profile test report can establish a patient’s baseline status and help practitioners customize protocols.

The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with 71 markers.  It provides an accurate evaluation of intestinal yeast and bacteria. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function. Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids in their urine. 

Our Organic Acids Test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels which are highly correlated with many chronic illnesses.

What Are the Benefits of Organic Acids Testing?

Organic acid testing provides insight into how well patients function metabolically. Practitioners can use insights from the Organic Acid Profile to personalize protocols to help patients improve dysfunctional pathways that may be contributing to current or future disease states.

Benefits of Organic Acid Testing Include:
  • Easiest way to test for organic acids: Organic acids are efficiently excreted through the kidneys as end products of metabolism. Evaluating organic acids in urine is a preferred and easy-to-collect testing option.
  • Organic acid testing provides practitioners with essential clues for targeted supplementation: Organic acids are produced endogenously during normal cellular metabolism and require dietary-derived vitamins, minerals, and other compounds as processing cofactors.
  • Helps to identify the flow of dysfunctional metabolic pathways: Catabolic products of essential amino acids in urine may help to identify the flow of dysfunctional metabolic pathways. Amino acid breakdown products can help gain insight into:
  • Nutrient cofactor needs
  • Methylation
  • Catecholamine turnover
  • Glutathione status
  • Level of Inflammation
  • Organic acid testing evaluates imbalances in the Krebs Cycle intermediate organic acids. Understanding imbalances in the Krebs Cycle can help identify location of impaired flow and possible impacts of the pathways.
  • Organic acid testing helps identify impacts on stress and mood disorders by providing information on neurotransmitter turnover and cortisol levels.
  • Organic acid testing helps identify potential gut-microbiome imbalance: Gut bacteria produce organic acids during their metabolic processing. Identification of these unique compounds can indicate potential gut-microbiome imbalances.
  • The Organic Acids Profile is Categorized by the Following Key Functional Areas of Patient Health:
  1. Metabolic Processing
  2. Amino Acid & Protein Metabolism
  3. Nutrition
  4. Stress & Mood
  5. Microbial Metabolites
  6. Toxic Impacts
Who Can Benefit from the Organic Acids Profile?
The Organic Acids Profile helps practitioners quickly identify dysfunctions that have been associated with a wide range of conditions. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function. Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids in their urine.

Metabolomics Research Has Evaluated the Following Conditions Associated With Organic Acid Testing:

  • Dysmetabolism, prediabetes, and diabetes
  • Weight changes and obesity
  • Fatigue
  • Athletic performance
  • Poor immune function
  • Depression and anxiety
  • GI microbial activity
  • Renal and liver dysfunction
  • Hyperactivity, Autism, etc
  • Autoimmunity 
Specimen Requirements
  • Urine – First-Morning-Void
  1. Tsoukalas D; Alegakis A; Fragkiadaki P; Papakonstantinou E; Nikitovic D; Karataraki A; Nosyrev AE; Papadakis EG; Spandidos DA; Drakoulis N; Tsatsakis AM; (n.d.). Application of metabolomics: Focus on the quantification of organic acids in healthy adults Int J Mol Med Retrieved November 11, 2021.
  2. U.S. National Library of Medicine. (n.d.). Amino acids MedlinePlus Retrieved November 11, 2021.
  3. Wu, G. (2018, April). Functional amino acids in nutrition and health Amino Acids Retrieved November 11, 2021.

Clish, C. B. (2015, October). Metabolomics: An emerging but powerful tool for precision medicine Cold Spring Harb Mol Case Stud Retrieved November 11, 2021.

Order an Organic Acid Test it is just a few simple step!


please enter the data where the Organic Acid set should be send


Detailed instructions and a return envelope you will find in the Organic Acid set


After 2-4 weeks, you will receive detailed Organic Acid analysis.

Autism Test FAQ's Functional Medicine Diagnostic FAQ's

Autism is a systemic body disorder that affects the brain.
Earlier the Medical community believed that autism was caused by “bad mothering” or the genes caused it. Today, there is enough scientific evidence that Autism is a whole body disorder triggered by a toxic environment, inflammatory food, blue light toxicity, infections, etc.
Several studies suggest autism is a whole body disorder. Besides impacting the social and cognitive abilities of the child, it is observed that affected individuals are also sensitive to food and environmental toxins due to poor linings in stomach and brain which results in full body symptoms like itching and dry skin, head sweats, bloating and upset stomach, urinary hesitancy, walking on toes, head banging, etc.
Autism is a spectrum disorder hence, symptoms can vary in severity and type from person to person. Most commonly seen symptoms of ASD are:
  • Difficulty with communication which could be inability to speak or delayed speech
  • Inappropriate use of gestures, eye contact, facial expressions, tone of voice
  • Difficulty recognizing, expressing and responding to emotions
  • Feeling uncomfortable in social situations
  • Extreme interest or non-interest in specific topics
  • Repetitive body movements (rocking, flapping hands or spinning)
  • Resistance to change
  • Specific food preferences or aversions
  • Sensory Processing differences
  • Immune system abnormalities
  • Gastrointestinal symptoms (constipation, loose stools, frequent stomach aches)
  • Lining up objects
  • Labile mood, increased tantrums or emotional outbursts
Several factors can increase the likelihood of a child suffering from Autism. The most common ones are:
  1. Gut dysbiosis: Children who have gastrointestinal issues have been seen to have a less diverse gut microbiome. The imbalance between the good and bad bacteria in the gut creates toxins that directly affect the brain.
  2. Toxins: Autistic children are more likely to accumulate harmful environmental toxins like lead, mercury, aluminium etc in their bodies, which can in turn cause their mitochondria to be less efficient in producing energy.
  3. Nutritional Deficiencies: Tendency of kids to have a narrow range of food leads them to nutrient deficient states. Deficiencies in nutrients needed for brain health like B vitamins, Omega 3 fats, zinc, magnesium and selenium are common.
  4. Food Sensitivities: Food sensitivities are often caused by the digestive lining becoming too leaky, allowing toxins, bacteria and incompletely digested particles of food into the bloodstream. A leaky gut also encourages autoimmune issues. It’s believed an attack by the immune system on brain cells, causing inflammation, could be a factor in some cases of autism.
  5. Oxidative Stress: Mitochondria is the powerhouse of energy. Brain requires a lot of energy for proper function. Mitochondrial dysfunction is commonly seen in autistic children.
There is an existence of a gut–brain axis, in which gut microbes produce bioactive compounds that influence brain function. Several researches have bolstered this theory, showing that when gut bacteria help to digest food, they generate a host of by-products that can affect thinking and behaviour. Researchers have also observed that some people with ASD could have an abnormally porous blood–brain barrier, which allows some toxic bacterial by-products to enter the bloodstream and reach the brain.
Parents play a central role in the intervention for Autism and Home is the prime centre for treating autism. The interventions that can be followed up by parents are:
  1. Diet: Parents should implement an autism diet, autism-specific nutrition, and specialized supplementation. Most parents begin with the GF/CF diet as children on the spectrum are usually highly allergic (or sensitive) to gluten and casein, the protein found in wheat, flour, and milk.
  2. Grounding: The simplest way of grounding involves walking or running barefoot outside on grass, sand or soil. Moist ground or grass is the perfect electrical conductor. Sitting Down Barefoot with your feet on grass or soil and avoid shoes with plastic and other soles are other ways of staying connected with earth.
  3. Monitoring screen time: Research shows that excess screen time results in over stimulation of the frontal lobe and an antagonist under development of the language centre in the brain. Limiting screen time also decreases exposure to toxic blue light which has an impact on gut microbiome.
Autism susceptibility is currently estimated to be 40–80% genetic. Environmental factors – likely acting through epigenetic regulation as the major mechanism – presumably compromise the remainder of the risk. Hundreds of potential environmental factors have been suggested to contribute to risk, such as increased parental age (especially paternal), maternal complications or infections during pregnancy. It has been said that genetics loads the gun, but environment is what pulls the trigger to cause autism in the majority of children.

There are historical differences between the term “Asperger’s” and what’s considered “autism.” Asperger’s was first introduced into the Diagnostic and Statistical Manual of Mental Disorders (DSM) in 1994, and was considered as a “mild” or “high-functioning” form of autism.

This happened because English psychiatrist Lorna Wing translated the works of Austrian physician Hans Asperger and realized his research found distinct characteristics in autistic children from those with “milder” symptoms. However, as of 2013, Asperger’s is now considered part of the autism spectrum and is no longer diagnosed as a separate condition. The only real “difference” between the two diagnoses is that people with Asperger’s may be considered as having an easier time “passing” as neurotypical with only “mild” signs and symptoms that may resemble those of autism.

Conventional diagnosis involves finding out whether the child’s behaviour meets a set of criteria for autism or ADHD, based on a set of questionnaires.

Functional Medicine approach is to individualize each and every autistic child and find the root cause of the imbalance. Tests commonly advised are to assess gut microbiome. Functional testing can also look at toxic load, nutritional status, food sensitivities, mitochondrial function and genetic susceptibility to poor detoxification.

Functional medicine approaches Autism as a whole body disorder and blood tests help in understanding the overall functioning of the entire body.
According to the Autism Society of America, “as there is no one symptom or behavior that identifies individuals with ASD, there is no single treatment that will be effective for all people on the spectrum. Individuals can learn to function within the confines of ASD and use the positive aspects of their condition to their benefit, but treatment must begin as early as possible and be tailored to the child’s unique strengths, weaknesses and needs.’’
Researchers say the chance of having autism spectrum disorder (ASD) appears to increase with the age of the parents when a child is born. It is believed that children born to older parents have a 50% higher chance of ASD.
Monitoring, screening, evaluating, and diagnosing children with ASD as early as possible is important to make sure children receive the services and support they need to reach their full potential. Many children show symptoms of autism by 12 months to 18 months of age or earlier, like poor eye contact or non responsiveness to their own name.

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Sample Collection

Sample collection will be done from home

Sample Processing

Sample is processed at Central Lab of our Trusted Partners.

Online Reporting

Reports are accessible online.

Sample Collection

Sample collection will be done from home

Sample Processing

Sample is processed at Central Lab of our Trusted Partners.

Online Reporting

Reports are accessible online.

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